Forensic Context

A study in rats demonstrated that the miR-495-5p is a potential intervention and diagnosis marker that inhibits inflammation, differentiation, and extracellular matrix accumulation of cardiac fibroblasts [Guo et al. DOI:10.1080/09168451.2020.1807901]. A study in humans demonstrated that a combination of circulating miRNAs, including the miR-495-5p, was significantly upregulated in patients with plaque rupture compared to those with plaque erosion, with a diagnostic model achieving an area under the ROC curve of 0.768 in an independent test set [Li et al. DOI:10.1016/j.ygeno.2020.11.019].