Basic Information

Symbol
hsa-mir-496
RNA class
miRNA miRNA hairpin
Alias
MIR496 MicroRNA 496 Hsa-Mir-496 MIRN496 Hsa-Mir-154-P20-V1_pre Hsa-Mir-154-P20-V2_pre MIMAT0002818 Hsa-MiR-496 MI0003136 Mir-496
Location (GRCh38)
1:40757284-40757372
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-496
Sequence length
102 nt
GC content
0.4216

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-43.90 kcal/mol
Thermodynamic ensemble
Free energy: -44.65 kcal/mol
Frequency: 0.3056
Diversity: 4.31
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((((...(((((.((((.((((((((.(((((..(((((((((........)))))))))..))))).)))))))).)))))))))........))))))
Thermodynamic Ensemble Prediction
((((((...(((((.((((.((((((((.(((((..(((((((((........)))))))))..))))).)))))))).)))))))))........))))))
Forensic Context

A study in human cell lines and peripheral blood mononuclear cells (PBMCs) demonstrated that the mir-496 directly targets two cooperative sites in the mTOR 3' UTR, reducing mTOR mRNA and protein levels, as well as downstream phospho-mTOR and phospho-p70S6K signaling in transfected HeLa-K cells [Rubie et al. DOI: 10.080/15384101.2016.1158360].