Basic Information

Symbol
hsa-mir-497
RNA class
miRNA miRNA hairpin
Alias
MIR497 MicroRNA 497 Hsa-MiR-497-5p Hsa-MiR-497-3p Hsa-Mir-497 MIRN497 Hsa-Mir-15-P1d_pre MIMAT0002820 MIMAT0004768 MI0003138 Mir-497
Location (GRCh38)
17:7017911-7018022
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Forensic psychiatry evaluation
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-497
Sequence length
112 nt
GC content
0.6696

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-55.10 kcal/mol
Thermodynamic ensemble
Free energy: -56.94 kcal/mol
Frequency: 0.0505
Diversity: 12.67
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...((.(((((((.((((((((((((((.((((.(((((((((.(((((......)))..)).))))))))).)))).)))).....).))))))))))))....)))).))
Thermodynamic Ensemble Prediction
,,.{,.(((((((.((((((((((((((.((((.(((((((((.(((((......)))..)).))))))))).)))).)))).....}.)))))))))))).))))..}.))
Forensic Context

A study in humans demonstrated that the mir-497 shows higher relative expression in menstrual blood than in peripheral blood, making it useful for distinguishing these two forensically relevant body fluids [Li et al. DOI:10.1007/s00414-021-02678-w]. In a separate human postmortem study, the mir-497 was found to be significantly decreased (0.724 of control, p=0.0395) in the prefrontal cortex of depressed suicide subjects, indicating its involvement in the altered miRNA network associated with this condition [Smalheiser et al. DOI:10.1371/journal.pone.0033201]. A review of human postmortem brain studies found that the mir-497 is upregulated in exosomes from Brodmann area 9 in subjects with schizophrenia and downregulated in Brodmann area 9 in subjects with major depressive disorder who died by suicide [Yoshino & Dwivedi DOI:10.3389/fpsyt.2020.543893].