Basic Information

Symbol
hsa-mir-4999
RNA class
miRNA miRNA hairpin
Alias
MIR4999 MicroRNA 4999 Hsa-Mir-4999 Hsa-MiR-4999-5p MIMAT0021017 MIMAT0021018 MI0017865 Mir-4999
Location (GRCh38)
10:133371556-133371663
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-4999
Sequence length
91 nt
GC content
0.2857

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-47.80 kcal/mol
Thermodynamic ensemble
Free energy: -48.74 kcal/mol
Frequency: 0.2162
Diversity: 15.78
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.......((((((((.(((((((((((((((((((((((((((.....))))))))))))))))))))))).)))).))))))))......
Thermodynamic Ensemble Prediction
.....,,((((((((,(((((((((((((((((((((((((((,...,))))))))))))))))))))))),)))),))))))})......
Forensic Context

A study in humans with coronary artery disease identified the mir-4999-3p as a biomarker for recurrent myocardial infarction risk, where it was downregulated in whole blood of patients with recurrent MI compared to those without in a replication cohort, remaining significant after false discovery rate correction (FDR <0.1), though it was not significantly different in plasma samples [Onuoha et al. DOI:10.1111/cts.13307].