Basic Information

Symbol
hsa-mir-500a
RNA class
miRNA miRNA hairpin
Alias
MIR500A MicroRNA 500a Hsa-MiR-500a-3p Hsa-MiR-500a-5p Hsa-Mir-500 MicroRNA 500 MIRN500 MIR500 Hsa-Mir-362-P2-V2_pre Hsa-Mir-362-P2-V1_pre Hsa-Mir-500a MIMAT0004773 MIMAT0002871 MI0003184 Mir-500a
Location (GRCh38)
19:53686469-53686555
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Individual identification Chronological age estimation
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-500a
Sequence length
84 nt
GC content
0.5595

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-37.80 kcal/mol
Thermodynamic ensemble
Free energy: -38.80 kcal/mol
Frequency: 0.1980
Diversity: 4.00
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((.(.(((((.(((((((((...(((((((....(((.........)))...))))))))))))))))..))))).).))))
Thermodynamic Ensemble Prediction
((((.(.(((((.(((((((((..{(((((((....(((.........)))...))))))))))))))))..))))).).))))
Forensic Context

A study in humans demonstrated that the mir-500a-3p is upregulated in whole blood of patients with recurrent myocardial infarction after percutaneous coronary intervention, showing significant differential expression after false-discovery rate correction [Onuoha et al. DOI:10.1111/cts.13307]. In a separate forensic investigation, the mir-500a-3p was found to be differentially expressed and shared across three pairs of monozygotic twins, indicating its potential as a biomarker for distinguishing genetically identical individuals in forensic identification [Xiao et al. DOI:10.1016/j.fsigen.2019.05.003]. A study in humans demonstrated that the mir-500a-3p is upregulated with age in peripheral whole blood samples and was validated as an age-related miRNA using RT-qPCR [Wang et al. DOI:10.3389/fgene.2022.1031806].