Basic Information

Symbol
hsa-mir-504
RNA class
miRNA miRNA hairpin
Alias
MIR504 MicroRNA 504 Hsa-Mir-504 Hsa-MiR-504-5p MIRN504 Hsa-Mir-504-V1_pre Hsa-Mir-504-V2_pre Hsa-MiR-504-3p MIMAT0026612 MIMAT0002875 MI0003189 Mir-504
Location (GRCh38)
19:53731006-53731090
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Sudden death from CNS diseases Mechanical injury analysis
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-504
Sequence length
83 nt
GC content
0.5542

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-53.00 kcal/mol
Thermodynamic ensemble
Free energy: -53.44 kcal/mol
Frequency: 0.4912
Diversity: 2.84
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
(((.((((((((((((((((.((((((((((.((.(((....))).))..)))))))))).)))))))))))).))))..)))
Forensic Context

A systematic review of studies in rats, mice, and humans identified aberrant expression profiles of 25 microRNAs, including the mir-504, in diabetes associated with male reproductive issues [Latifi et al. DOI:10.1007/s11033-024-10197-1]. A study in Wistar rats demonstrated that plasma exosomal miR-504 expression increased within 30 minutes post-acute myocardial infarction (AMI) and was used in a machine learning model for early AMI identification and duration inference, achieving high precision [Zhou et al. DOI:10.007/s00414-025-03583-2]. Separately, a systematic review and meta-analysis in humans identified miR-504 as a reported diagnostic biomarker for severe traumatic brain injury (TBI) from cerebellar tissue, contributing to the overall high diagnostic accuracy of miRNAs for TBI [Zhou et al. DOI:10.7150/ijms.48214].