Forensic Context

A systematic review of studies in rats, mice, and humans identified aberrant expression profiles of 25 microRNAs, including the mir-504, in diabetes associated with male reproductive issues [Latifi et al. DOI:10.1007/s11033-024-10197-1]. A study in Wistar rats demonstrated that plasma exosomal miR-504 expression increased within 30 minutes post-acute myocardial infarction (AMI) and was used in a machine learning model for early AMI identification and duration inference, achieving high precision [Zhou et al. DOI:10.007/s00414-025-03583-2]. Separately, a systematic review and meta-analysis in humans identified miR-504 as a reported diagnostic biomarker for severe traumatic brain injury (TBI) from cerebellar tissue, contributing to the overall high diagnostic accuracy of miRNAs for TBI [Zhou et al. DOI:10.7150/ijms.48214].