Basic Information

Symbol
hsa-mir-506
RNA class
miRNA miRNA hairpin
Alias
MIR506 MicroRNA 506 Hsa-MiR-506-3p Hsa-Mir-506 MIRN506 Hsa-Mir-506-P1_pre Hsa-MiR-506-5p MIMAT0002878 MIMAT0022701 MI0003193 Mir-506
Location (GRCh38)
4:20528275-20528384
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-506
Sequence length
124 nt
GC content
0.4194

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-43.10 kcal/mol
Thermodynamic ensemble
Free energy: -45.33 kcal/mol
Frequency: 0.0267
Diversity: 12.93
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((((((...........(((((((((.(((.((((((((((.(((((..((((.(((((....)))))))))))))).)))))))))).)))...))).)))))).........))))))))
Thermodynamic Ensemble Prediction
((((((((.,.........(((((((((.(((.((((((((((.(((((..((({{(((((....)))))))))))))).)))))))))).)))...)))},))))).........))))))))
Forensic Context

A study in human patients with second-degree burns demonstrated that the mir-506 was downregulated in burn tissues compared to normal tissues, and its expression increased following treatment with an artificial skin membrane, correlating with improved wound healing and reduced fibrosis markers [Li et al. DOI:10.1002/jcla.24564]. A review of human skin burns identified the mir-506 as downregulated in third-degree burn skin within 24 hours post-burn and in heat-treated human skin fibroblast cell lines [Siu et al. DOI:10.1111/wrr.13100]. Separately, a time-series analysis of gene expression in human severe burn patients identified the mir-506 as a top miRNA with a high degree of connectivity in the sustained increasing gene (SIG) network during recovery, suggesting its role in the molecular regulation of the post-burn immunosuppressive state [Xu et al. DOI:10.1159/000493451].