Basic Information

Symbol
hsa-mir-508
RNA class
miRNA miRNA hairpin
Alias
MIR508 MicroRNA 508 Hsa-MiR-508-5p Hsa-Mir-508 MIRN508 Hsa-Mir-506-P3_pre Hsa-MiR-508-3p MIMAT0004778 MIMAT0002880 MI0003195
Location (GRCh38)
X:147236913-147237027
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification Forensic psychiatry evaluation Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-508
Sequence length
115 nt
GC content
0.4522

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-49.20 kcal/mol
Thermodynamic ensemble
Free energy: -50.06 kcal/mol
Frequency: 0.2463
Diversity: 3.85
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((((....((((((((((.(((.((((((((((((((..((.((((((........)))))).))..)))))))))))))).))).))))).)))......))......)))))
Thermodynamic Ensemble Prediction
(((((....((((((((((.(((.((((((((((((((..((.((((((........)))))).))..)))))))))))))).))).))))).)))......}}......)))))
Forensic Context

A review of human studies identified 197 miRNAs associated with wound healing, burn healing, and scarring, with specific dysregulation patterns observed in human skin tissue and cell lines post-thermal injury [Siu et al. DOI:10.1111/wrr.13100]. A study in human postmortem prefrontal cortex demonstrated that the mir-508-3p is down-regulated in schizophrenia (fold-change 0.48), bipolar disorder (fold-change 0.53), and major depression (fold-change 0.43) [Smalheiser et al. DOI:10.1371/journal.pone.0086469]. In a separate human study, a related isoform, miR-508-5p, was confirmed as an alcohol use disorder-associated miRNA in the amygdala [Lim et al. DOI:10.1038/s41398-021-01635-w].