Basic Information

Symbol
hsa-mir-126
RNA class
miRNA miRNA hairpin
Alias
MIR126 MicroRNA 126 Hsa-MiR-126-5p Hsa-MiR-126-3p Hsa-Mir-126 MIRN126 Hsa-Mir-126-P2-V2_pre Hsa-Mir-126-P2-V3_pre Hsa-Mir-126-P2-V1_pre MIMAT0000445 MIMAT0000444 MI0000471 MiRNA126 Mir-126
Location (GRCh38)
9:136670602-136670686
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Cause of death analysis Wound age identification Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-126
Sequence length
85 nt
GC content
0.5294

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-40.10 kcal/mol
Thermodynamic ensemble
Free energy: -41.25 kcal/mol
Frequency: 0.1555
Diversity: 3.22
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.((((..(((((..(((((((((((.(((((((.....(((....)))....))))))).)))))))))))..)))))..)))).
Thermodynamic Ensemble Prediction
.((((,.(((((..(((((((((((.(((((((.{.,.(((....)))..}.))))))).)))))))))))..))))),.)))).
Forensic Context

A study in humans demonstrated that the mir-126 exhibits higher expression in blood samples (peripheral and menstrual) compared to other body fluids and was successfully used for body fluid identification within a probabilistic model achieving high prediction accuracy [Li et al. DOI:10.1007/s00414-021-02678-w]. Another study in humans found the mir-126 was down-regulated in denatured dermis from burn patients compared to normal skin, with real-time RT-PCR validation showing a decrease to 0.46-fold [Liang et al. DOI:10.1016/j.burns.2011.10.014]. A study in human skin wound biopsies and HaCaT keratinocytes demonstrated that the mir-126 is upregulated during wound healing and promotes keratinocyte proliferation and migration by directly targeting PLK2 and activating the PI3K/AKT signaling pathway [Chang et al. DOI:10.1002/cbin.11088]. In a separate human study of acute myocardial infarction, plasma levels of the mir-126 were negatively correlated with disease severity markers (Gensini score, BNP, LDL-C, cTnI), and specific gene polymorphisms (rs4636297 and rs1140713) were associated with AMI risk and circulating mir-126 levels [Haiqiang Hu et al. DOI:10.1089/gtmb.2018.0282].