Basic Information

Symbol
hsa-mir-511
RNA class
miRNA miRNA hairpin
Alias
MIR511 MicroRNA 511 Hsa-Mir-511-1 Hsa-Mir-511-2 MicroRNA 511-2 MicroRNA 511-1 Hsa-MiR-511-5p MIRN511-1 MIRN511-2 MIR511-1 MIR511-2 Hsa-Mir-511_pre Hsa-MiR-511-3p MIMAT0002808 MIMAT0026606 Hsa-Mir-511 MI0003127 Mir-511
Location (GRCh38)
14:100884702-100884783
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Forensic psychiatry evaluation Cause of death analysis Other applications
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-511
Sequence length
87 nt
GC content
0.3908

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-33.00 kcal/mol
Thermodynamic ensemble
Free energy: -34.39 kcal/mol
Frequency: 0.1047
Diversity: 6.53
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((.(((..((((..(((((((((((.((((.(((.((((......))))))).)))).)))))))))))..))))..))).))))
Thermodynamic Ensemble Prediction
((((.(((.,((((..(((((((((((.{(((.(((.{(((......))}}))).)))}.)))))))))))..)))).,))).))))
Forensic Context

A study in humans demonstrated that the mir-511 was significantly decreased in the prefrontal cortex of depressed suicide subjects compared to non-psychiatric controls, with expression measured at 0.598 of control levels [Smalheiser et al. DOI:10.1371/journal.pone.0033201]. A separate human study identified the mir-511 as an immune-related miRNA in serum exosomes, showing it was downregulated in septic shock compared to sepsis and, in combination with miR-193b-5p, provided an area under the curve of 0.795 for diagnosing sepsis versus controls [Li et al. DOI:10.1038/s41598-025-89946-6]. A study in mice demonstrated that the mir-511 was differentially expressed at both 6h and 24h after γ-irradiation in blood and was also present in the intersection group between 6 h γ-irradiation and 56Fe irradiation [Jia et al. DOI:10.3389/fcell.2022.861451]. In human postmortem brain research, the mir-511 was found to be upregulated in the Edinger-Westphal nucleus of subjects with major depressive disorder who died by suicide, where it targets GFRA1 [Yoshino et al. DOI:10.3389/fpsyt.2020.543893].