Basic Information

Symbol
hsa-mir-517b
RNA class
miRNA miRNA hairpin
Alias
MIR517B MicroRNA 517b Hsa-MiR-517-5p Hsa-Mir-517b MIRN517B Hsa-Mir-430-P35b_pre Hsa-MiR-517a-3p Hsa-MiR-517b-3p MIMAT0002857 MIMAT0002851 MI0003165 Mir-517b
Location (GRCh38)
19:53741313-53741407
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-517b
Sequence length
67 nt
GC content
0.4478

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-26.30 kcal/mol
Thermodynamic ensemble
Free energy: -27.26 kcal/mol
Frequency: 0.2098
Diversity: 2.80
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
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Forensic Context

A review of human studies identified the mir-517b as a biomarker of organophosphate pesticide exposure, where its expression in urine was positively associated with farmworker status and trended towards a positive dose response with pesticide metabolites [Kotsyfakis et al. DOI:10.1080/1354750X.2019.1652348]. A study in humans demonstrated that mir-517b was detectable in 57% of urine samples from farmworker and non-farmworker adults and children, and was upregulated in farmworker adults during the post-harvest season, showing a 15-fold increase compared to non-farmworkers and a positive dose-response trend with total organophosphate pesticide metabolites [Weldon et al. DOI:10.1016/J.Taap.2016.01.018].