A study in human postmortem serum demonstrated that exosomes and exosomal miRNAs, including the miR-5195-5p, are stably preserved for at least three days when stored at or below 20°C, and subsequent miRNA profiling in acute myocardial infarction (AMI) cadavers identified 18 significantly upregulated and 16 significantly downregulated exosomal miRNAs compared to controls, providing a novel perspective for determining the cause of death [Kanno et al. DOI:10.1007/S00414-022-02913-Y].