Basic Information

Symbol
hsa-mir-521-1
RNA class
miRNA miRNA hairpin
Alias
MIR521-1 MicroRNA 521-1 Hsa-Mir-521-1 Hsa-MiR-521 MIRN521-1 Hsa-Mir-430-P29a_pre MIMAT0002854 Mir-521-1 MI0003176 hsa-mir-521
Location (GRCh38)
19:53748636-53748722
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-521-1
Sequence length
87 nt
GC content
0.4483

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-35.30 kcal/mol
Thermodynamic ensemble
Free energy: -36.32 kcal/mol
Frequency: 0.1912
Diversity: 3.97
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((((.((.(((((.(((.(((((((((..(.((((....(((...)))..)))).)..))))))))).))).))))).)).)))))
Thermodynamic Ensemble Prediction
{((((.((.(((((.(((.(((((((((..(.((((....(({...)))..)))).)..))))))))).))).))))).)).))))}
Forensic Context

A study in mice demonstrated that the mir-521 was significantly changed in prostate cancer cells in response to ionizing radiation, where it sensitizes cells by regulating the DNA repair protein CSA [Lu et al. DOI:10.1002/cbin.10627]. A study in prostate cancer cells demonstrated that inhibition of the mir-521 confers radioresistance by targeting the DNA repair protein CSA [May et al. DOI:10.1016/j.trsl.2021.02.005].