Basic Information

Symbol
hsa-mir-539
RNA class
miRNA miRNA hairpin
Alias
MIR539 MicroRNA 539 Hsa-MiR-539-5p Hsa-MiR-539-3p Hsa-Mir-539 MIRN539 Hsa-Mir-154-P21_pre MIMAT0003163 MIMAT0022705 MI0003514 Mir-539
Location (GRCh38)
14:101047321-101047398
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Wound age identification
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-539
Sequence length
78 nt
GC content
0.3077

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-28.50 kcal/mol
Thermodynamic ensemble
Free energy: -30.14 kcal/mol
Frequency: 0.0697
Diversity: 6.19
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((((((((((((((((.((((((.(((((((((.........).)))).)))))))))).)))))))))))))))))
Thermodynamic Ensemble Prediction
{((((((((((((((((.((((({{((((((((,.........).)))).)))))))))).))))))))))))))))}
Forensic Context

A review of human studies identified the mir-539 as being upregulated in burn hypertrophic scar tissue compared to normal skin [Siu et al. DOI:10.1111/wrr.13100]. A study in mice demonstrated that the mir-539 was down-regulated -2.02-fold in the hippocampus at 4 hours after traumatic brain injury under normal temperature conditions, but showed no significant change under low-temperature conditions [Wang et al. DOI:10.1258/ebm.2012.012123]. In a separate study in rats, the mir-539 was identified as one of several microRNAs upregulated 1 day after contusion spinal cord injury [Hu et al. DOI:10.1089/neu.2012.2748].