Basic Information

Symbol
hsa-mir-127
RNA class
miRNA miRNA hairpin
Alias
MIR127 MicroRNA 127 Hsa-MiR-127-5p Hsa-MiR-127-3p Hsa-Mir-127 MIRN127 Hsa-Mir-127_pre MIMAT0004604 MIMAT0000446 MI0000472 MiRNA127 Mir-127
Location (GRCh38)
14:100882979-100883075
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Sudden death from CNS diseases
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-127
Sequence length
97 nt
GC content
0.5258

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-40.70 kcal/mol
Thermodynamic ensemble
Free energy: -42.42 kcal/mol
Frequency: 0.0614
Diversity: 16.81
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((.(((...(((.(((.(((.(((((((((.((.((((((((.....))..)))))).)).)))))))))))).))).))))))...))))).
Thermodynamic Ensemble Prediction
.(((((.(((..,(((,(((.{{{.(((((((((.((.(((((({(.....)}..)))))).)).)))))))))))),))}.))})))...))))).
Forensic Context

A study in human myocardial autopsy specimens from septic patients demonstrated that hsa-miR-127-3p was down-regulated in septic hearts compared to non-septic controls [Lehto et al. DOI:10.1038/s41598-024-81114-6]. In human skin research, hsa-miR-127-3p was found upregulated in burn hypertrophic scar and its derived fibroblasts versus normal fibroblasts [Siu et al. DOI:10.1111/wrr.13100]. A study in rodents demonstrated that the mir-127 is downregulated after spinal cord injury, which should lead to increased inflammation [Nieto-Diaz et al. DOI:10.3389/fncel.2014.00053].