Forensic Context

A study in humans with coronary artery disease identified the miR-541-5p as a biomarker for recurrent myocardial infarction risk, where it was downregulated in whole blood of patients with recurrent MI compared to those without, remaining significant after false-discovery rate correction, though it was not significantly different in plasma samples [Onuoha et al. DOI:10.1111/cts.13307]. A study in rats demonstrated that heroin self-administration significantly upregulated the miR-541-5p in the orbitofrontal cortex of both male and female subjects, as validated by qPCR and RNase R digestion assays, identifying it as a heroin-responsive circular RNA [Floris et al. DOI:10.3390/ijms23031453].