Forensic Context

A review of human studies identified 197 miRNAs associated with wound healing, burn wound healing, and scarring, with specific miRNAs like the miR-542-3p being upregulated in burn hypertrophic scar tissue versus normal skin and in venous ulcers versus normal skin and acute wounds [Siu et al. DOI:10.1111/wrr.13100]. In a rat model of burn-induced myocardial damage, transcriptome sequencing identified 23 differentially expressed miRNAs in cardiac tissue, and ROC analysis demonstrated that rno-miR-341, rno-miR-344b-3p, and rno-miR-190b-3p exhibited high sensitivity and specificity for diagnosing this condition [Guo et al. DOI:10.1080/09168451.2020.1807901]. A review of literature indicates the miR-542-3p is induced in the serum of alcohol-exposed human mothers [Mandal et al. DOI:10.1002/JAT.3504] and is also upregulated in human venous ulcers compared to normal skin and acute wounds [Siu et al. DOI:10.1111/WRR.13100].