Forensic Context

A study in humans demonstrated that hsa-miR-542-5p was significantly increased in the plasma of acute myocardial infarction patients compared to healthy controls, identifying it as a potential biomarker for MI [Baulina et al. DOI:10.1016/j.yjmcc.2018.07.129]. A separate review of human studies reported that hsa-miR-542-5p was upregulated in burn hypertrophic scar tissue compared to normal skin, associating it with scarring processes [Siu et al. DOI:10.1111/wrr.13100]. In a separate pilot study using a Göttingen minipig model of lethal total body irradiation, ssc-miR-542-5p was identified as an early marker, showing down-regulation in the early and mid phases post-exposure [Chakraborty et al. DOI:10.1038/s41598-023-45250-9].