Basic Information

Symbol
hsa-mir-543
RNA class
miRNA miRNA hairpin
Alias
MIR543 MicroRNA 543 Hsa-Mir-543 Hsa-MiR-543 MIRN543 Hsa-Mir-154-P22_pre MIMAT0004954 MI0005565 Mir-543
Location (GRCh38)
X:114639435-114639519
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Other applications
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-543
Sequence length
78 nt
GC content
0.3846

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-24.90 kcal/mol
Thermodynamic ensemble
Free energy: -26.80 kcal/mol
Frequency: 0.0456
Diversity: 9.99
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((.((.(((((((.(((((((..(.((((((.........).))))).)..))))).))))))))).)).))))..
Thermodynamic Ensemble Prediction
((((.((.((((((,,(((((((..(.((((((.........),))))).}..))))).))))))))).)}.))))..
Forensic Context

A study in human patients with heart failure after acute myocardial infarction demonstrated that the mir-543 was significantly upregulated in peripheral blood mononuclear cells from individuals exhibiting sacubitril/valsartan resistance compared to non-resistant patients, as validated by quantitative real-time PCR [Su et al. DOI:10.1016/j.ejphar.2023.175547]. A study in rhesus macaques demonstrated that the mir-543 was utilized in a model to predict the future development of pleural effusion following whole thorax irradiation, achieving high accuracy in a Day 15 prediction model [May et al. DOI:10.1038/s41598-022-16316-x].