Basic Information
Symbol
hsa-miR-543
RNA class
miRNA
mature miRNA
Alias
hsa-miR-543
MIR543
MicroRNA 543
Location (GRCh38)
-
Forensic tag(s)
Sudden cardiac death diagnosis
Other applications
External database
Sequence & Structure
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-24.90 kcal/mol
Thermodynamic ensemble
Free energy:
-26.80 kcal/mol
Frequency:
0.0456
Diversity:
9.99
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((.((.(((((((.(((((((..(.((((((.........).))))).)..))))).))))))))).)).))))..
Thermodynamic Ensemble Prediction
((((.((.((((((,,(((((((..(.((((((.........),))))).}..))))).))))))))).)}.))))..
Forensic Context
A study in human patients with heart failure after acute myocardial infarction demonstrated that the miR-543 was significantly upregulated in peripheral blood mononuclear cells from individuals exhibiting sacubitril/valsartan resistance compared to non-resistant patients, as validated by quantitative real-time PCR [Su et al. DOI:10.1016/j.ejphar.2023.175547]. A study in rhesus macaques demonstrated that the miR-543 was utilized in a model to predict the future development of pleural effusion following whole thorax irradiation, achieving high accuracy in a Day 15 prediction model [May et al. DOI:10.1038/s41598-022-16316-x].