Basic Information

Symbol
hsa-mir-545
RNA class
miRNA miRNA hairpin
Alias
MIR545 MicroRNA 545 Hsa-MiR-545-5p Hsa-MiR-545-3p Hsa-Mir-545 MIRN545 Hsa-Mir-95-P3-V1_pre Hsa-Mir-95-P3-V2_pre MIMAT0003165 MIMAT0004785 MI0003516 Mir-545
Location (GRCh38)
19:53695213-53695293
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Forensic psychiatry evaluation
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-545
Sequence length
106 nt
GC content
0.4151

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-35.60 kcal/mol
Thermodynamic ensemble
Free energy: -37.16 kcal/mol
Frequency: 0.0795
Diversity: 9.86
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.....((((((((.((((((((((.((((((((((((.((.(((((.............))))))).)))))))))))).).))))))))).))).....).))))
Thermodynamic Ensemble Prediction
.....((((((((.((((((((((.((((((((((((.{{.(((((.............)))))}}.)))))))))))).).))))))))).))).,,..,.})))
Forensic Context

A study in humans demonstrated that the mir-545 was downregulated by 30% or more in the prefrontal cortex of antidepressant-free depressed suicide subjects compared to non-psychiatric controls, though this decrease did not reach statistical significance (p>0.05) [Smalheiser et al. DOI:10.1371/journal.pone.0033201].