Forensic Context

A study in humans demonstrated that the miR-545-3p was differentially expressed and shared across two pairs of monozygotic twins, suggesting a role for this microRNA in distinguishing genetically identical individuals in forensic identification [Xiao et al. DOI:10.1016/j.fsigen.2019.05.003]. In a separate study using a Göttingen minipig model of lethal total body irradiation, the miR-545-3p was identified as an early marker of radiation exposure, showing down-regulation in the early and mid post-exposure phases and being linked to processes such as cell migration, proliferation, and invasion [Chakraborty et al. DOI:10.1038/s41598-023-45250-9].