Forensic Context

A review of human studies identified 197 miRNAs associated with wound healing, burn wound healing, and scarring, with specific miRNAs like hsa-miR-21 and hsa-miR-31 upregulated in hypertrophic scar tissue and shown to promote keratinocyte proliferation and migration [Siu et al. DOI:10.1111/wrr.13100]. In non-small-cell lung cancer, the long non-coding RNA MIAT was significantly increased in tumor tissues and its SNP rs1061541 C-containing genotypes were protective, while MIAT functioned as a competing endogenous RNA by sponging miR-133a-5p to modulate MYO1B, SGK1, and WNT9A expression [Zheng et al. DOI:10.2147/CMAR.S163395]. A study in humans demonstrated that the mir-548a is differentially expressed within monozygotic twin pairs, with its expression shared across two pairs of twins, supporting its potential role in forensic identification [Xiao et al. DOI:10.1016/j.fsigen.2019.05.003]. Another study in humans found that the mir-548a was associated with longitudinal phenotypic decline, showing a negative beta coefficient reflecting decreased functionality over time with higher baseline levels [La Grotta et al. DOI:10.1016/j.mad.2025.112099].