Forensic Context

A review of human studies identified 197 miRNAs associated with wound healing, burn wound healing, and scarring, with specific expression patterns validated in human skin tissue and cell lines using qRT-PCR, microarrays, and next-generation sequencing [Siu et al. DOI:10.1111/wrr.13100]. A study in humans demonstrated that the miR-550b-3p is differentially expressed between monozygotic twins, as microarray analysis of blood samples from 18 pairs identified it among 53 miRNAs shared across three twin pairs, and subsequent qRT-PCR validation confirmed its differential expression in 7 to 8 out of 18 pairs using a 1.5-fold change criterion [Xiao et al. DOI:10.1016/j.fsigen.2019.05.003].