Basic Information

Symbol
hsa-mir-551b
RNA class
miRNA miRNA hairpin
Alias
MIR551B MicroRNA 551b Hsa-MiR-551b-3p Hsa-MiR-551b-5p Hsa-Mir-551b MIRN551B Hsa-Mir-551-P2_pre MIMAT0004794 MIMAT0003233 MI0003575 Mir-551b
Location (GRCh38)
1:71067631-71067716
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Wound age identification Mechanical injury analysis
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-551b
Sequence length
96 nt
GC content
0.5313

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-39.80 kcal/mol
Thermodynamic ensemble
Free energy: -40.96 kcal/mol
Frequency: 0.1523
Diversity: 4.98
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
........((((.(((((..((((((((((.((((((....((((........))))......)))))).))))))))))..))))).))))....
Thermodynamic Ensemble Prediction
........((((.{((((..((((((((((.((((((,...((((........))))....}.)))))).))))))))))..))))).))))....
Forensic Context

A study in human postmortem serum demonstrated that exosomal hsa-miR-551b-5p was significantly upregulated (2.64-fold) in acute myocardial infarction (AMI) autopsy cases compared to hemorrhagic shock controls [Kanno et al. DOI:10.1007/S00414-022-02913-Y]. In separate human skin research, the mir-551b was identified as downregulated in hypertrophic scar tissue compared to normal tissue [Siu et al. DOI:10.1111/wrr.13100]. A study in rats demonstrated that the mir-551b was down-regulated (>1.5-fold) in the hippocampus at 1, 3, and 5 days following traumatic brain injury, identifying it as a potential marker for TBI progression [Sun et al. DOI:10.1007/s11596-014-1313-1].