Basic Information

Symbol
hsa-mir-557
RNA class
miRNA miRNA hairpin
Alias
MIR557 MicroRNA 557 Hsa-Mir-557 Hsa-MiR-557 MIRN557 MIMAT0003221 MI0003563
Location (GRCh38)
1:198858873-198858982
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-557
Sequence length
98 nt
GC content
0.5408

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-29.80 kcal/mol
Thermodynamic ensemble
Free energy: -32.03 kcal/mol
Frequency: 0.0270
Diversity: 14.94
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
....((..(....)..)).....(((((((((..(((((((.((((((((((.....))))...))).))).))))))))))))))))..........
Thermodynamic Ensemble Prediction
.....,..,.......||.....(((((((((..{((((((.((((((,(({.....}}}}...))).))).))))))})))))))))......,,..
Forensic Context

A study in humans identified the mir-557 as significantly upregulated, showing a 9.60-fold increase in denatured dermis from deep partial-thickness burn patients compared to paired normal skin [Liang et al. DOI:10.1016/j.burns.2011.10.014]. A subsequent review confirmed this finding, reporting the mir-557 was upregulated in human deep partial-thickness burn skin four days post-injury [Siu et al. DOI:10.1111/wrr.13100].