A study in humans identified the mir-578 as a potential biomarker predicted to bind the up-regulated circRNAs hsa_circRNA_104700 and hsa_circRNA_102315 in sepsis-induced acute respiratory distress syndrome [Guo et al. DOI:10.1016/j.lfs.2021.119566]. A separate review highlighted that in human breast cancer, circZFR promotes progression via a miR-578/HIF1A axis [Huang et al. DOI:10.3390/cells11091381].