Basic Information

Symbol
hsa-mir-582
RNA class
miRNA miRNA hairpin
Alias
MIR582 MicroRNA 582 Hsa-MiR-582-3p Hsa-MiR-582-5p Hsa-Mir-582 MIRN582 Hsa-Mir-582-V2_pre Hsa-Mir-582-V1_pre MIMAT0003247 MIMAT0004797 MI0003589
Location (GRCh38)
5:59703606-59703703
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Sudden death from CNS diseases Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-582
Sequence length
98 nt
GC content
0.3571

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-44.00 kcal/mol
Thermodynamic ensemble
Free energy: -44.79 kcal/mol
Frequency: 0.2757
Diversity: 3.19
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...(((((((((((....(((((((((((((((((((..............)))))))))))))))))))....))))))))))).............
Thermodynamic Ensemble Prediction
...(((((((((((..,.(((((((((((((((((((..............))))))))))))))))))).,..))))))))))).............
Forensic Context

A study in human vascular endothelial cells demonstrated that the mir-582 was significantly upregulated (fold change 41.92) in exosomes derived from cells under heat stroke temperature conditions, identifying it as a potential noninvasive biomarker for heat stroke [Chen et al. DOI:10.12659/MSM.909983]. In human patients with acute spinal cord injury, the mir-582 was significantly upregulated in plasma at emergency room admission compared to healthy controls, as validated by droplet digital PCR, indicating its potential as a specific biomarker for this neurotrauma [Hörauf et al. DOI:10.3390/ijms262210954]. In a rat model of burn injury, transcriptome sequencing of myocardial tissue revealed that the mir-582 was significantly upregulated in the injury group, further supporting its role as a potential biomarker for myocardial damage [Guo et al. DOI:10.1080/09168451.2020.1807901].