A study in rats demonstrated that the miR-582-5p was significantly upregulated in myocardial tissue following burn injury and was identified as a potential biomarker for myocardial damage [Guo et al. DOI:10.1080/09168451.2020.1807901]. In human vascular endothelial cells, the miR-582-5p was significantly upregulated in exosomes under heat stroke temperature conditions and was identified as a noninvasive biomarker for heat stroke [Chen et al. DOI:10.12659/MSM.909983].