Forensic Context

A study in preterm human newborns with early-onset neonatal sepsis demonstrated that the mir-584 was significantly down-regulated in cord blood plasma of the sepsis group compared to controls [Janec et al. DOI:10.14712/fb2023069050173]. In a separate study of adult human patients, serum exosomal miRNA sequencing identified the mir-584 as being up-regulated in both sepsis and septic shock patients compared to healthy controls, highlighting its crucial role in septic shock [Li et al. DOI:10.1038/s41598-025-89946-6]. A study in rhesus macaques demonstrated that the mir-584 was utilized as a feature in a three-group survival prediction model at Day 3 post-thoracic irradiation, which achieved 71% accuracy in forecasting whether an animal would die in less than 90 days, between 90 and 269 days, or survive the 270-day study [May et al. DOI:10.1038/s41598-022-16316-x].