Forensic Context

A study in preterm human newborns with early-onset neonatal sepsis demonstrated that the miR-584-5p was significantly down-regulated in cord blood plasma of the sepsis group compared to gestational age-matched controls [Janec et al. DOI:10.14712/fb2023069050173]. In a separate study of adult human patients, serum exosomal miRNA sequencing identified the miR-584-5p as being significantly up-regulated in both sepsis and septic shock patients compared to healthy controls, and it was highlighted for having a crucial role in septic shock [Li et al. DOI:10.1038/s41598-025-89946-6]. A study in humans using massively parallel sequencing identified the miR-584-5p as an absolute specific marker for venous blood, demonstrating high specificity and very high expression [Liu et al. DOI:10.3390/genes13091530].