Basic Information

Symbol
hsa-mir-589
RNA class
miRNA miRNA hairpin
Alias
MIR589 MicroRNA 589 Hsa-MiR-589-3p Hsa-MiR-589-5p Hsa-Mir-589 MIRN589 Hsa-Mir-589_pre MIMAT0004799 MIMAT0003256 MI0003599 Mir-589
Location (GRCh38)
1:168375524-168375621
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Mechanical injury analysis
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-589
Sequence length
99 nt
GC content
0.6263

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-41.10 kcal/mol
Thermodynamic ensemble
Free energy: -42.29 kcal/mol
Frequency: 0.1462
Diversity: 7.70
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((.((......(((((..(((.(((((.(((.((.(((((((.((......)).))))))).)).)))..))))).)))..))))))))))))..
Thermodynamic Ensemble Prediction
.(((({{((......(((((..(((.(((((.(((.((.(((((((.(({,...,)),))))))).)).)))..))))).)))..))))))))))))..
Forensic Context

A study in severely injured human patients demonstrated that the mir-589 was differentially expressed and showed a direct correlation with TLR3 gene expression (P = .01) [Uhlich et al. DOI:10.1016/j.surg.2014.06.017]. In a separate human study of coronary artery disease, the mir-589 was upregulated in the whole blood of patients with recurrent myocardial infarction and remained significant after false discovery rate correction, with associations noted for atherosclerosis and regulation by NRF2 [Onuoha et al. DOI:10.1111/cts.13307]. In a separate human study, the mir-589 was identified as downregulated in the plasma of patients with coronary artery disease compared to controls with normal coronary arteries [Zhong et al. DOI:10.1002/jcla.23020].