Forensic Context

A study in humans with coronary artery disease demonstrated that the miR-589-5p was upregulated in whole blood of patients with recurrent myocardial infarction after percutaneous coronary intervention, with this differential expression being significant after false-discovery rate correction in a replication cohort [Onuoha et al. DOI:10.1111/cts.13307]. This miRNA is associated with atherosclerosis and is regulated by NRF2, indicating its role in vascular disease pathways and its potential as a prognostic biomarker for thrombotic risk when profiled from whole blood samples.