Basic Information

Symbol
hsa-mir-590
RNA class
miRNA miRNA hairpin
Alias
MIR590 MicroRNA 590 Hsa-MiR-590-3p Hsa-MiR-590-5p Hsa-Mir-590 MIRN590 Hsa-Mir-590_pre MIMAT0003258 MIMAT0004801 MI0003602 Mir-590
Location (GRCh38)
14:101033755-101033836
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Chronological age estimation Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-590
Sequence length
97 nt
GC content
0.3505

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-31.20 kcal/mol
Thermodynamic ensemble
Free energy: -32.78 kcal/mol
Frequency: 0.0765
Diversity: 5.26
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
....((((((((.((.(((((((.(((((((.(((((..(((.....)))..))))).))))))).))))))).)).))))))))............
Thermodynamic Ensemble Prediction
....((((((((.((.(((((((.(((((((.(((((..(({.....}))..))))).))))))).))))))).)).))))))))............
Forensic Context

A study in humans demonstrated that the mir-590 was significantly negatively correlated with age in peripheral blood from physiologically unaffected individuals, with a correlation of -0.486 and a raw P value of 6.97E-07 [Meder et al. DOI:10.1373/clinchem.2014.224238]. A study in humans demonstrated that plasma exosomal miR-4516, miR-203, and SFRP1 levels were significantly elevated in acute myocardial infarction patients and exhibited high diagnostic efficiency, with exo-miR-4516 also correlating with coronary lesion severity [Liu et al. DOI:10.3892/mmr.2023.13010]. The literature also notes that the mir-590 is associated with cardiac function recovery post-AMI by inducing mitosis, as referenced in introductory discussions [Jia et al. DOI:10.3389/fcell.2022.861451].