Basic Information
Symbol
hsa-miR-596
RNA class
miRNA
mature miRNA
Alias
hsa-miR-596
MIR596
MicroRNA 596
Location (GRCh38)
-
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Sequence & Structure
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-36.40 kcal/mol
Thermodynamic ensemble
Free energy:
-37.33 kcal/mol
Frequency:
0.2216
Diversity:
4.24
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
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Forensic Context
A study in humans with coronary artery disease identified the miR-596 as a biomarker for recurrent myocardial infarction risk, where it was downregulated in whole blood of patients with recurrent MI compared to those without, with this differential expression remaining significant after false discovery rate correction (FDR <0.1) [Onuoha et al. DOI:10.1111/cts.13307]. The investigation found no significant differential expression for the miR-596 in plasma samples from the same cohort, indicating whole blood as the preferred sample source for this biomarker in the context of cardiovascular risk assessment.