Basic Information

Symbol
hsa-mir-598
RNA class
miRNA miRNA hairpin
Alias
MIR598 MicroRNA 598 Hsa-Mir-598 Hsa-MiR-598-3p Hsa-MiR-598-5p MIRN598 Hsa-Mir-598_pre MIMAT0003266 MIMAT0026620 MI0003610 Mir-598
Location (GRCh38)
8:11035206-11035302
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Cause of death analysis
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-598
Sequence length
97 nt
GC content
0.5361

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-36.10 kcal/mol
Thermodynamic ensemble
Free energy: -38.09 kcal/mol
Frequency: 0.0398
Diversity: 14.19
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.((((((((......(((((.((((((((((..((((((((((.(((........)))..))))))))))..)))))))))).))))))))).))))
Thermodynamic Ensemble Prediction
.(((((((({,....{((((.((((((((((..((((((((({.(({........}}},}))))))))))..)))))))))).)))))))))},))}
Forensic Context

A study in humans demonstrated that the mir-598 was significantly decreased in the plasma of male acute myocardial infarction patients compared to healthy controls, as identified by next-generation sequencing [Baulina et al. DOI:10.1016/j.yjmcc.2018.07.129]. In the context of ionizing radiation injury, research in mice showed that the mir-598 was differentially expressed in blood 6 hours after γ-irradiation and was also significantly down-regulated in human peripheral blood lymphocytes 24 hours post-irradiation under microgravity conditions [Jia et al. DOI:10.3389/fcell.2022.861451].