Forensic Context

A study in humans analyzing denatured dermis from deep partial-thickness burn patients four days post-injury identified the mir-601 as significantly upregulated, showing a 42.41-fold increase compared to paired normal skin [Liang et al. DOI:10.1016/j.burns.2011.10.014]. This differential expression was part of a broader miRNA profiling effort that identified 66 differentially expressed miRNAs, with the mir-601 being one of the most substantially upregulated, suggesting its involvement in early post-burn molecular pathways related to wound healing and tissue response. A study in humans demonstrated that the mir-601 is associated with age-related functional decline, showing a negative correlation with age in a review of transcriptomic data [Solovev et al. DOI:10.1016/j.mad.2019.111192]. In a separate human study of older monozygotic twins, the mir-601 was specifically validated as being associated with reduced endurance function in activity of daily living scores, with a negative beta coefficient in cross-sectional analysis [La Grotta et al. DOI:10.1016/j.mad.2025.112099].