Forensic Context

A study in humans demonstrated that the miR-615-3p is a top downregulated miRNA in the plasma of acute myocardial infarction patients compared to non-AMI controls, with qRT-PCR validation confirming this expression pattern [Zhong et al. DOI:10.1002/jcla.23099]. The diagnostic efficacy of the miR-615-3p was supported by receiver operating characteristic analysis, yielding an area under the curve of 0.688, indicating its potential value as a circulating diagnostic biomarker for this condition.