Forensic Context

A study in humans demonstrated that serum levels of the mir-625 were significantly upregulated in patients with mild traumatic brain injury at baseline compared to controls, with a progressive reduction at 24 and 48 hours post-injury, identifying it as a sensitive and specific biomarker for monitoring the post-trauma period [Polito et al. DOI:10.1007/s11033-020-05386-7]. Another human study found that pericardial-fluid-derived exosomal the mir-625 was significantly increased in subjects with acute myocardial infarction compared to controls, indicating its potential as a biomarker for postmortem diagnosis of ischemic heart disease [Kim et al. DOI:10.3390/ijms25179619]. A study in humans demonstrated that the mir-625 is positively associated with hand grip strength in older monozygotic twins, with higher expression correlating with improved physical function in cross-sectional analyses [La Grotta et al. DOI:10.1016/j.mad.2025.112099]. Research in forensic medicine has identified numerous non-coding RNAs, including miRNAs, as potential biomarkers for tissue and body fluid identification, cause-of-death analysis, time-related estimation, age estimation, and the identification of monozygotic twins [Song et al. DOI:10.1007/s00414-023-03091-1].