Forensic Context

A study in humans demonstrated that the mir-625-5p was significantly downregulated (5.053-fold) in pericardial-fluid-derived exosomes from acute myocardial infarction patients compared to controls, identifying it as a potential biomarker for postmortem diagnosis [Kim et al. DOI:10.3390/ijms25179619]. In traumatic brain injury research, the mir-625-5p was also identified as downregulated in exosomes from the serum of chronic mild TBI patients, indicating its potential as a diagnostic biomarker across different biofluids and conditions [Li et al. DOI:10.1016/j.neuint.2023.105643]. A study in humans demonstrated that the mir-625-5p is significantly upregulated in the prefrontal cortex of subjects with schizophrenia and in suicide subjects compared to controls [Smalheiser et al. DOI:10.1371/journal.pone.0086469]. In a separate human study of older monozygotic twins, the mir-625-5p was positively associated with hand grip strength in cross-sectional analyses, suggesting improved physical function with higher expression [La Grotta et al. DOI:10.1016/j.mad.2025.112099].