Basic Information

Symbol
hsa-mir-128-2
RNA class
miRNA miRNA hairpin
Alias
MIR128-2 MicroRNA 128-2 Hsa-MiR-128-3p Hsa-Mir-128-2 Hsa-Mir-128b MicroRNA 128b MIRN128-2 MIRN128B Hsa-Mir-128-P1_pre Hsa-MiR-128-2-5p MIMAT0000424 MIMAT0031095 Mir-128-2 MI0000727 Mir-128b MIR128B hsa-mir-128-2 hsa-mir-128b
Location (GRCh38)
3:35744476-35744559
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Forensic psychiatry evaluation
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-128-2
Sequence length
84 nt
GC content
0.5595

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-39.30 kcal/mol
Thermodynamic ensemble
Free energy: -40.64 kcal/mol
Frequency: 0.1130
Diversity: 10.42
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...((((((((.((((((((((...((((((..((((.(........).))))))))))...)))))))))).))))))))...
Thermodynamic Ensemble Prediction
...((((((((,((((((((((.,.((((((..((((.(........).)))))))))).,.)))))))))),))})))))...
Forensic Context

A study in rats demonstrated that the mir-128b is up-regulated after fear conditioning and its expression is significantly affected by extinction training, with knockdown impairing the formation of fear-extinction memory [Wang et al. DOI:10.1101/Lm.026492.112]. Research also indicates that the mir-128b is induced in the prefrontal cortex after fear extinction training, where it may inhibit plasticity-related genes associated with the retrieval of the original fear memory [Bredy et al. DOI:10.1016/J.Nlm.2011.04.004].