Basic Information

Symbol
hsa-mir-642b
RNA class
miRNA miRNA hairpin
Alias
MIR642B MicroRNA 642b Hsa-MiR-642b-3p Hsa-MiR-642b-5p Hsa-Mir-642b MIMAT0018444 MIMAT0022736 MI0016685 Mir-642b
Location (GRCh38)
19:45674932-45675008
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-642b
Sequence length
77 nt
GC content
0.5584

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-60.20 kcal/mol
Thermodynamic ensemble
Free energy: -60.26 kcal/mol
Frequency: 0.9086
Diversity: 0.23
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
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Forensic Context

A study in humans demonstrated that the mir-642b-5p is upregulated in postischemic left ventricular myocardium following acute ischemia during cardiac surgery [Saddic et al. DOI:10.1152/physiolgenomics.00049.2015]. In a separate human study, the mir-642b-5p was identified as a potential biomarker for sacubitril/valsartan resistance, showing upregulation in the peripheral blood mononuclear cells of heart failure patients with this resistance compared to non-resistant patients [Su et al. DOI:10.1016/j.ejphar.2023.175547].