Basic Information

Symbol
hsa-mir-645
RNA class
miRNA miRNA hairpin
Alias
MIR645 MicroRNA 645 Hsa-Mir-645 MIRN645 MIMAT0003315 Hsa-MiR-645 MI0003660
Location (GRCh38)
12:80935736-80935833
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification Individual identification
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-645
Sequence length
94 nt
GC content
0.5638

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-42.80 kcal/mol
Thermodynamic ensemble
Free energy: -44.41 kcal/mol
Frequency: 0.0735
Diversity: 7.89
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
....((((...((((.((((..(((((((((((((.(((..(((((((...)))))))))).))))))))))))))))).))))....)).)).
Thermodynamic Ensemble Prediction
...,(({{...((((.((((..(((((((((((((.(((..(((((((...)))))))))).))))))))))))))))).))))....,).},.
Forensic Context

A review of human studies identified 197 miRNAs associated with wound healing, burn wound healing, and scarring, with specific expression patterns validated in human skin tissue and cell lines using qRT-PCR, microarrays, and next-generation sequencing [Siu et al. DOI:10.1111/wrr.13100]. A study in humans identified the mir-645 as a biomarker of longitudinal phenotypic decline, where its higher baseline expression was associated with decreased physical functionality over time in older monozygotic twins [La Grotta et al. DOI:10.1016/j.mad.2025.112099].