Basic Information
Symbol
hsa-miR-645
RNA class
miRNA
mature miRNA
Alias
hsa-miR-645
MIR645
MicroRNA 645
Location (GRCh38)
-
Forensic tag(s)
Wound age identification
Other applications
External database
Sequence & Structure
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-42.80 kcal/mol
Thermodynamic ensemble
Free energy:
-44.41 kcal/mol
Frequency:
0.0735
Diversity:
7.89
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
....((((...((((.((((..(((((((((((((.(((..(((((((...)))))))))).))))))))))))))))).))))....)).)).
Thermodynamic Ensemble Prediction
...,(({{...((((.((((..(((((((((((((.(((..(((((((...)))))))))).))))))))))))))))).))))....,).},.
Forensic Context
A review of human studies identified 197 miRNAs associated with wound healing, burn wound healing, and scarring, with specific expression patterns validated in human skin tissue and cell lines using qRT-PCR, microarrays, and next-generation sequencing [Siu et al. DOI:10.1111/wrr.13100]. A study in humans identified the miR-645 as a biomarker of longitudinal phenotypic decline, where its higher baseline expression was associated with decreased physical functionality over time in older monozygotic twins [La Grotta et al. DOI:10.1016/j.mad.2025.112099].