Basic Information

Symbol
hsa-mir-652
RNA class
miRNA miRNA hairpin
Alias
MIR652 MicroRNA 652 Hsa-MiR-652-5p Hsa-MiR-652-3p Hsa-Mir-652 MIRN652 Hsa-Mir-652_pre MIMAT0003322 MIMAT0022709 MI0003667
Location (GRCh38)
7:93482760-93482855
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Chronological age estimation Cause of death analysis
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-652
Sequence length
98 nt
GC content
0.5000

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-53.10 kcal/mol
Thermodynamic ensemble
Free energy: -53.98 kcal/mol
Frequency: 0.2401
Diversity: 3.94
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
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Forensic Context

A study in severely injured human patients demonstrated that the mir-652 was differentially expressed and showed a strong direct correlation with TLR3 gene expression (P < .0004; rho = 0.84) and a direct correlation with MyD88 (P = .04) [Uhlich et al. DOI:10.1016/j.surg.2014.06.017]. A separate investigation in physiologically unaffected humans found that the mir-652 showed a positive correlation with age in a high-throughput sequencing cohort (correlation 0.368, P = 0.004), though this finding was discordant with a microarray platform from the same study [Meder et al. DOI:10.1373/clinchem.2014.224238]. In a rat model of atherosclerotic death, the mir-652 was identified as a key biomarker via LASSO regression, contributing to a diagnostic model with an 82% area under the curve for identifying this condition [Zhao et al. DOI:10.3390/cimb47110889].