Forensic Context

A study in humans demonstrated that the miR-652-3p was significantly positively correlated with age in peripheral blood from physiologically unaffected individuals when measured by high-throughput sequencing (correlation 0.368, P value 0.004), though it showed a discordant negative correlation in an earlier microarray analysis [Meder et al. DOI:10.1373/clinchem.2014.224238]. In a separate human study, the miR-652-3p was found to be up-regulated in myocardial autopsy specimens from patients deceased with sepsis compared to non-septic controls [Pasi Lehto et al. DOI:10.1038/s41598-024-81114-6]. A study in mice demonstrated that the miR-652-3p is part of a 14-miRNA plasma signature identified at day 1 post-irradiation that segregates animals by radiation dose and correlates with later clinical injury scores and skin perfusion [Ancel et al. DOI:10.1371/journal.pone.0329737]. In human forensic research, the miR-652-3p was evaluated as one of ten candidate endogenous reference RNAs for miRNA expression normalization across five body fluids, though it was not among the top-ranked most stable genes in the final comprehensive analysis [Wei et al. DOI:10.1016/j.fsigen.2023.102827].