Forensic Context

A study in severely injured human patients demonstrated that the mir-652 was differentially expressed and showed a strong direct correlation with TLR3 gene expression (P < .0004; rho = 0.84) and a direct correlation with MyD88 (P = .04) [Uhlich et al. DOI:10.1016/j.surg.2014.06.017]. A separate investigation in physiologically unaffected humans found that the mir-652 showed a positive correlation with age in a high-throughput sequencing cohort (correlation 0.368, P = 0.004), though this finding was discordant with a microarray platform from the same study [Meder et al. DOI:10.1373/clinchem.2014.224238]. In a rat model of atherosclerotic death, the mir-652 was identified as a key biomarker via LASSO regression, contributing to a diagnostic model with an 82% area under the curve for identifying this condition [Zhao et al. DOI:10.3390/cimb47110889].