A study in human denatured dermis from deep burn patients identified the mir-659 as significantly up-regulated, showing a 14.29-fold increase compared to normal skin [Liang et al. DOI:10.1016/j.burns.2011.10.014]. This differential expression profile, alongside other dysregulated miRNAs, provides an experimental basis for understanding the molecular mechanisms of functional recovery in thermal-injured skin [Wang and Zhou DOI:10.1007/s00438-024-02183-w].