Basic Information

Symbol
hsa-mir-660
RNA class
miRNA miRNA hairpin
Alias
MIR660 MicroRNA 660 Hsa-MiR-660-3p Hsa-MiR-660-5p Hsa-Mir-660 MIRN660 Hsa-Mir-188-P3_pre MIMAT0022711 MIMAT0003338 MI0003684 Mir-660
Location (GRCh38)
11:122099757-122099844
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Forensic psychiatry evaluation
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-660
Sequence length
97 nt
GC content
0.4948

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-32.80 kcal/mol
Thermodynamic ensemble
Free energy: -34.20 kcal/mol
Frequency: 0.1038
Diversity: 5.74
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..((((.((((((.....((((.((((((.((((.(((...........))).)))).))))))))))......)))))).))))............
Thermodynamic Ensemble Prediction
..((((.((((((..,,.(((,{((((((.((((.(((...........))).)))).))))))))))..,,..)))))).))))............
Forensic Context

A study in humans demonstrated that the mir-660 was significantly downregulated in the prefrontal cortex of antidepressant-free depressed suicide subjects compared to non-psychiatric controls, with expression measured at 0.811 of control (p=0.0277) [Smalheiser et al. DOI:10.1371/journal.pone.0033201]. A study in humans demonstrated that the mir-660 was downregulated in the BA9 region of the brain in subjects with major depressive disorder who died by suicide [Yoshino & Dwivedi DOI:10.3389/fpsyt.2020.543893]. In a separate human study investigating sacubitril/valsartan resistance in heart failure patients, the mir-660 was identified as a potential biomarker, though its expression change was not consistent with initial microarray data during qRT-PCR validation in peripheral blood mononuclear cells [Su et al. DOI:10.1016/j.ejphar.2023.175547].